Why the study?
Does night-time ingestion of antihypertensives improve blood pressure and left ventricular parameters compared to morning ingestion in Nigerian hypertensives?
Population
Ambulant grade 1 and 2 hypertensives, entirely African cohort (Nigerian)
Comparison
Night-time ingestion of once-daily… vs Morning intake of once-daily antihypertensives
Design
RCT, Randomized after a washout period into morning or night-time ingestion…
Follow-up
12 weeks
Authors
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Supports night-time antihypertensive dosing in Nigerian hypertensives; extends chronotherapy evidence to African cohorts.
Does night-time ingestion of antihypertensives improve blood pressure and left ventricular parameters compared to morning ingestion in Nigerian hypertensives?
Night-time dosing of antihypertensives in an African cohort resulted in better reductions in blood pressure and left ventricular mass compared to standard morning dosing.
Okeahialam et al. (2011) studied this question.
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