Chronotherapy With Nifedipine GITS in Hypertensive Patients: Improved Efficacy and Safety With Bedtime Dosing
Why the study?
Does nifedipine GITS administered at bedtime improve blood pressure reduction and reduce edema compared to morning administration in untreated hypertensive patients?
Population
180 untreated hypertensive patients (86 men and 94 women), mean age 52.5 +/- 10.7 years
Comparison
Nifedipine GITS 30 mg/day monotherapy… vs Nifedipine GITS 30 mg/day monotherapy…
Design
RCT, randomly assigned
Follow-up
8 weeks
Authors
Discussion
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Member takes
Implication
Bedtime nifedipine GITS improves nocturnal BP control with far less edema; extends chronotherapy evidence in hypertension.
Structured PICO
Does nifedipine GITS administered at bedtime improve blood pressure reduction and reduce edema compared to morning administration in untreated hypertensive patients?
P
Population
180 untreated hypertensive patients (86 men and 94 women), mean age 52.5 +/- 10.7 years
I
Intervention
Nifedipine GITS 30 mg/day monotherapy administered at bedtime for 8 weeks
C
Comparator
Nifedipine GITS 30 mg/day monotherapy administered upon awakening for 8 weeks
O
Outcome
Blood pressure reduction after 8 weeks of treatment measured by 48-hour ambulatory blood pressure monitoringsurrogate
Bedtime administration of nifedipine GITS in hypertensive patients improves ambulatory blood pressure control and significantly reduces the incidence of edema compared to morning dosing.
Cite This Study
Hermida et al. (2008) studied this question.