October 1, 1990American Journal of Hypertension

Nifedipine Gastrointestinal Therapeutic System in the Treatment of Hypertension

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Why the study?

Does nifedipine GITS reduce blood pressure in patients with mild-to-moderate hypertension?

Population

1155 patients with mild-to-moderate hypertension

Design

Cohort

Follow-up

18 weeks (6 weeks titration plus 12 weeks observation)

Authors

LKLawrence R. KrakoffMount Sinai Hospital EBEmmanuel L. BravoCleveland Clinic MTMichael L. TuckGeneral / Preventive / Lipids

Discussion

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Implication

Nifedipine GITS may lower BP in mild-to-moderate hypertension; leaves open efficacy versus alternatives pending randomized trials.

Structured PICO

Does nifedipine GITS reduce blood pressure in patients with mild-to-moderate hypertension?

Population

1155 patients with mild-to-moderate hypertension

Intervention

Nifedipine GITS (gastrointestinal therapeutic system) started at 30 mg/day and titrated to a maximum dose of 180 mg/day over 6 weeks, followed by 12 weeks of treatment

Outcome

Goal blood pressure response (sitting diastolic blood pressure < 90 mm Hg and a decrease of ≥10 mm Hg)surrogate

Nifedipine GITS is an effective and well-tolerated once-daily monotherapy for reducing blood pressure in patients with mild-to-moderate hypertension.

Cite This Study

Krakoff et al. (1990) studied this question.

synapsesocial.com/papers/6a916973ae2c4ed52ef1306e https://doi.org/10.1093/ajh/3.10.318

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Nifedipine Gastrointestinal Therapeutic System in the Treatment of Hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Nifedipine Gastrointestinal Therapeutic System in the Treatment of Hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider