Population
Male CD-1 mice
Comparison
Beta-guanidinopropionic acid administered in… vs Control mice
Design
Preclinical
Follow-up
7 weeks
Authors
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Indicates differential skeletal versus cardiac response to energetic stress in rodents; leaves open translation to human cardiac adaptation.
Administration of the creatine analogue beta-GPA induces significant adaptive changes in the isomyosin phenotype of skeletal muscle, but not cardiac muscle, indicating a role for intracellular energetics in muscle adaptation.
Moerland et al. (1989) studied this question.
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