October 9, 2001CirculationOpen Access

Chronic Phosphocreatine Depletion by the Creatine Analogue β-Guanidinopropionate Is Associated With Increased Mortality and Loss of ATP in Rats After Myocardial Infarction

View Full Paper

Ask AI

Bookmark

Why the study?

Does phosphocreatine depletion by beta-guanidinopropionate impair mechanical function and ATP homeostasis in rats after myocardial infarction?

Population

Rats subjected to sham operation or left coronary artery ligation (MI) to induce a heart failure model

Comparison

Feeding with 1% beta-guanidinopropionate for 8… vs 0% GP feeding (Sham or MI)

Design

Preclinical

Follow-up

8 weeks

Authors

MHMichael HornUniversity of Bern HRHelga RemkesUniversitätsklinikum Würzburg HSHinrik StrömerPraxis für Humangenetik

Discussion

Member takes

Implication

Severe PCr depletion precludes post-MI survival in rats; leaves open whether CK modulation affects human outcomes.

Structured PICO

Does phosphocreatine depletion by beta-guanidinopropionate impair mechanical function and ATP homeostasis in rats after myocardial infarction?

Population

Rats subjected to sham operation or left coronary artery ligation (MI) to induce a heart failure model

Intervention

Feeding with 1% beta-guanidinopropionate (GP) for 8 weeks after MI, or for 2 or 4 weeks before MI

Comparator

0% GP feeding (Sham or MI)

Outcome

Left ventricular pressure-volume curves and high-energy phosphate metabolism (PCr content, Flux(CK), ATP levels) at 8 weekssurrogate

Severe depletion of myocardial phosphocreatine content prevents survival after acute MI and impairs ATP homeostasis in chronically infarcted hearts.

Cite This Study

Horn et al. (2001) studied this question.

synapsesocial.com/papers/6a77917f576efb0ddaf77338 https://doi.org/10.1161/hc3901.095933

View Full Paper

Ask AI

Bookmark

Chronic Phosphocreatine Depletion by the Creatine Analogue β-Guanidinopropionate Is Associated With Increased Mortality and Loss of ATP in Rats After Myocardial Infarction

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Chronic Phosphocreatine Depletion by the Creatine Analogue β-Guanidinopropionate Is Associated With Increased Mortality and Loss of ATP in Rats After Myocardial Infarction

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider