Key result
Enalapril treatment almost completely reversed the 67% decrease in creatine kinase flux seen in untreated cardiomyopathic hamster hearts, which was coupled to improved cardiac performance.
Why the study?
Does enalapril improve isovolumic contractile performance and creatine kinase flux in Syrian myopathic hamsters with advanced heart failure?
Population
7-month-old Syrian cardiomyopathic (TO-2 strain) and normal golden Syrian (FIB strain) hamsters
Comparison
Enalapril daily at low or high doses for 12 to… vs No enalapril treatment
Design
Preclinical, randomly assigned
Follow-up
12 to 14 weeks
Authors
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May support ACEI use in advanced HF energetics; leaves open translation from animal models to patients.
RCT
Randomly assigned
Does enalapril improve isovolumic contractile performance and creatine kinase flux in Syrian myopathic hamsters with advanced heart failure?
Enalapril treatment in failing hamster myocardium increases phosphoryl transfer through the creatine kinase reaction, which is coupled to improved cardiac performance.
Nascimben et al. (1995) conducted an RCT in Advanced Heart Failure. Enalapril vs. No enalapril was evaluated on Isovolumic contractile performance and flux through the creatine kinase (CK) system. Enalapril treatment almost completely reversed the 67% decrease in creatine kinase flux seen in untreated cardiomyopathic hamster hearts, which was coupled to improved cardiac performance.
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