Key result
In a turkey poult model of dilated cardiomyopathy, baseline isovolumic contractile performance decreased by 73% and creatine kinase reaction velocity decreased by 71%.
Why the study?
Does decreased energy reserve via the creatine kinase system contribute to reduced cardiac function in an animal model of dilated cardiomyopathy?
Population
One-week-old turkey poults fed furazolidone for 14 days to induce dilated cardiomyopathy, and a separate…
Comparison
Furazolidone-induced dilated cardiomyopathy and… vs Normal baseline performance/control
Design
Preclinical
Follow-up
14 days
Authors
Loading...
Supports CK energetics as DCM target; hypothesis-generating in avian model, leaves open translation.
Does decreased energy reserve via the creatine kinase system contribute to reduced cardiac function in an animal model of dilated cardiomyopathy?
In an animal model of dilated cardiomyopathy, decreased energy reserve via the creatine kinase system contributes to reduced cardiac function and blunted contractile reserve.
Liao et al. (1996) studied Dilated cardiomyopathy. Furazolidone was evaluated on Isovolumic contractile performance and creatine kinase reaction velocity. In a turkey poult model of dilated cardiomyopathy, baseline isovolumic contractile performance decreased by 73% and creatine kinase reaction velocity decreased by 71%.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: