November 2, 1999Circulation
Downregulation of the Na + -Creatine Cotransporter in Failing Human Myocardium and in Experimental Heart Failure
Why the study?
Is creatine transporter protein downregulated in failing human myocardium and experimental heart failure?
Population
Explanted human hearts with dilated cardiomyopathy and healthy donor hearts, and rats 2 months after left…
Comparison
Heart failure condition vs Nonfailing controls
Design
Preclinical
Follow-up
2 months (for rat model)
Authors
Discussion
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Member takes
Implication
Supports impaired energetics in experimental HF; leaves open confirmation in human myocardium.
Structured PICO
Is creatine transporter protein downregulated in failing human myocardium and experimental heart failure?
P
Population
Explanted human hearts with dilated cardiomyopathy (n=8) and healthy donor hearts (n=8), and rats 2 months after left anterior descending coronary artery ligation (n=8) or sham operation (n=6).
I
Intervention
Heart failure condition (dilated cardiomyopathy in humans, post-myocardial infarction in rats)
C
Comparator
Nonfailing controls (healthy donor hearts in humans, sham operation in rats)
O
Outcome
Creatine transporter protein quantity and total creatine contentsurrogate
Creatine transporter protein is downregulated in both human and experimental heart failure, contributing to reduced energy reserve in the failing myocardium.
Cite This Study
Neubauer et al. (1999) studied this question.