Why the study?
Does elevation of myocardial creatine by targeting the creatine transporter protect against ischaemia/reperfusion injury and heart failure in mice?
Population
Mice overexpressing creatine transporter in the heart and wild-type mice subjected to acute and chronic…
Comparison
Overexpression of creatine transporter resulting… vs Wild-type mice
Design
Preclinical
Authors
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No immediate clinical implications; leaves open whether CrT targeting protects human hearts from I/R injury.
Does elevation of myocardial creatine by targeting the creatine transporter protect against ischaemia/reperfusion injury and heart failure in mice?
Elevating myocardial creatine by 20-100% via creatine transporter overexpression protects against ischaemia/reperfusion injury in mice, suggesting a potential therapeutic target.
Lygate et al. (2012) studied this question.
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