March 1, 2018Cardiovascular ResearchOpen Access

Over-expression of mitochondrial creatine kinase in the murine heart improves functional recovery and protects against injury following ischaemia–reperfusion

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Why the study?

Does over-expression of mitochondrial creatine kinase improve functional recovery and reduce infarct size in a murine model of ischaemia-reperfusion injury?

Population

Mice over-expressing the sarcomeric MtCK gene with αMHC promoter at the Rosa26 locus and wild-type littermates

Comparison

Over-expression of mitochondrial creatine kinase vs Wild-type (WT) littermates

Design

Preclinical

Authors

HWHannah J. WhittingtonMolecular Oncology (United States)POPhilip J. OstrowskiGreat Ormond Street Hospital for Children NHS Foundation Trust DMDebra J. McAndrewCentre for Human Genetics

Discussion

Member takes

Implication

Hypothesis-generating for MtCK as cardioprotective target; leaves open translation to human ischemia-reperfusion injury.

Structured PICO

Does over-expression of mitochondrial creatine kinase improve functional recovery and reduce infarct size in a murine model of ischaemia-reperfusion injury?

Population

Mice over-expressing the sarcomeric MtCK gene with αMHC promoter at the Rosa26 locus (MtCK-OE) and wild-type (WT) littermates

Intervention

Over-expression of mitochondrial creatine kinase (MtCK)

Comparator

Wild-type (WT) littermates

Outcome

Functional recovery (Rate pressure product) and myocardial infarct size following 20 min ischaemia and 30 min reperfusionsurrogate

Over-expression of mitochondrial creatine kinase in mice protects against ischaemia-reperfusion injury and improves functional recovery by modifying mPTP opening.

Cite This Study

Whittington et al. (2018) studied this question.

synapsesocial.com/papers/6a894d5c40fe6a3effcafe29 https://doi.org/10.1093/cvr/cvy054

Topics

Cardiac MRI

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Over-expression of mitochondrial creatine kinase in the murine heart improves functional recovery and protects against injury following ischaemia–reperfusion

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Over-expression of mitochondrial creatine kinase in the murine heart improves functional recovery and protects against injury following ischaemia–reperfusion

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Topics

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