Why the study?
Does chronic high-dose creatine feeding prevent left ventricular remodeling and energy metabolism derangement in a rat model of post-myocardial infarction heart failure?
Population
Rats subjected to sham operation or left coronary artery ligation, n=27
Comparison
3% creatine feeding for 8 weeks vs 0% creatine (untreated) diet for 8 weeks
Design
Preclinical
Follow-up
8 weeks
Authors
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Creatine fails to prevent post-MI remodeling or energetic decline in rats; leaves open any therapeutic role in human heart failure.
Does chronic high-dose creatine feeding prevent left ventricular remodeling and energy metabolism derangement in a rat model of post-myocardial infarction heart failure?
Chronic high-dose creatine feeding does not prevent functional and energetic derangements or left ventricular remodeling in a rat model of post-myocardial infarction heart failure.
Michael Horn (1999) studied this question.
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