Impairment of energy metabolism in intact residual myocardium of rat hearts with chronic myocardial infarction.
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Key result
In chronically infarcted rat hearts, ATP content remained unchanged while creatine phosphate was reduced by 31% and creatine kinase reaction velocity fell by 50% in the residual intact myocardium.
Why the study?
Does chronic myocardial infarction impair energy metabolism in the residual intact myocardium of rats?
Population
12-week-old Wistar rats with chronic myocardial infarction induced by left anterior descending coronary…
Comparison
Chronic myocardial infarction followed by… vs Sham-operated rats undergoing identical…
Design
Preclinical
Follow-up
8 weeks
Authors
Discussion
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Implication
May increase susceptibility to acute metabolic stress in post-MI rats; hypothesis-generating for chronic energetics in larger models.
Structured PICO
Does chronic myocardial infarction impair energy metabolism in the residual intact myocardium of rats?
P
Population
12-week-old Wistar rats with chronic myocardial infarction induced by left anterior descending coronary artery (LAD) ligation, evaluated 8 weeks post-infarction.
I
Intervention
Chronic myocardial infarction (LAD ligation) followed by isolated heart perfusion and acute metabolic stress (hypoxia).
C
Comparator
Sham-operated rats undergoing identical procedures without LAD ligation.
O
Outcome
Energy metabolism parameters (ATP, creatine phosphate, creatine kinase activity, phosphoryl exchange) and contractile performance in residual intact myocardium.surrogate
Main Result
Absolute Event Rate: 29.4% vs 42.5%
p-value: p=<0.05
Energy reserve is substantially impaired in the residual intact myocardium of chronically infarcted rats, which contributes to an increased susceptibility to acute metabolic stress.
Limitations
- Global left ventricular measures were used instead of regional function
- Regional blood flow was not measured
- 31P-NMR spectra represent average metabolic estimates for the entire heart including intact and scarred myocardium
Cite This Study
Neubauer et al. (1995) studied Chronic myocardial infarction (n=75). Myocardial infarction (LAD ligation) vs. Sham operation was evaluated on Creatine phosphate (CP) content (nmol/mg protein) (p=<0.05). In chronically infarcted rat hearts, ATP content remained unchanged while creatine phosphate was reduced by 31% and creatine kinase reaction velocity fell by 50% in the residual intact myocardium.
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