Key result
Chronic coronary stenosis and MI impair global LV mitochondrial respiration and increase glycogen accumulation.
Why the study?
The study investigated whether mitochondrial function and structure are altered in myocardium adjacent to MI with reduced perfusion and in remote nonischemic myocardium after MI remodeling.
Population
13 pigs with chronic coronary stenosis and MI and 14 sham-operated pigs
Comparison
Myocardium adjacent to MI and remote nonischemic myocardium vs sham-operated controls
Design
Preclinical experimental study in a pig model
Follow-up
6 weeks
Authors
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Global post-MI mitochondrial and glycogen changes appear load-driven in pigs; leaves open human mechanistic and therapeutic relevance.
Following myocardial infarction, reduced mitochondrial respiration and glycogen accumulation occur globally in the left ventricle, suggesting increased hemodynamic load rather than reduced perfusion is the primary driver of these changes.
Galan et al. (2016) studied Myocardial infarction (n=27). Chronic coronary stenosis and myocardial infarction vs. Sham operation was evaluated on Mitochondrial function and structure (oxygen consumption rate, glycogen content). Chronic coronary stenosis and myocardial infarction in a pig model reduced mitochondrial respiration and increased glycogen accumulation in all left ventricular regions compared to sham.
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