Why the study?
Does greater collagen-induced platelet aggregation following COX1 inhibition predict incident acute coronary syndromes in healthy individuals with a family history of early-onset coronary artery disease?
Population
1,699 healthy individuals with a family history of early-onset coronary artery disease
Design
Cohort
Follow-up
6±1.2 years
Authors
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Should not yet guide risk stratification or therapy; leaves open whether this pathway is modifiable in primary prevention.
Does greater collagen-induced platelet aggregation following COX1 inhibition predict incident acute coronary syndromes in healthy individuals with a family history of early-onset coronary artery disease?
Greater collagen-induced platelet aggregation following aspirin therapy independently predicts incident acute coronary syndromes in healthy individuals with a family history of early-onset CAD.
Qayyum et al. (2014) studied this question.
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