Why the study?
Does dexamethasone abolish the insulin-induced increase in coronary flow reserve in young men with uncomplicated type 1 diabetes?
Population
21 non-smoking men
Comparison
Dexamethasone 2 mg/day for two days prior to… vs Assessment without previous dexamethasone…
Design
Other
Authors
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Supports sympathetic regulation of insulin effects on coronary perfusion in type 1 diabetes; hypothesis-generating and should not change practice.
Does dexamethasone abolish the insulin-induced increase in coronary flow reserve in young men with uncomplicated type 1 diabetes?
Dexamethasone abolishes the insulin-induced increase in coronary flow reserve in young men with type 1 diabetes, suggesting sympathetic activation regulates insulin's effects on myocardial perfusion in this population.
Laine et al. (2004) studied this question.
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