Why the study?
Does dexamethasone pretreatment abolish the insulin-induced increment of coronary flow reserve in healthy young men?
Population
16 healthy nonobese men, mean age 34 +/- 4 years, with normal left ventricular mass, function, and stress…
Comparison
Dexamethasone 2 mg per day for 2 days prior to… vs No previous medication prior to euglycemic…
Design
Other
Authors
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Dexamethasone does not blunt insulin-mediated coronary flow in healthy men; leaves open sympathetic mediation and clinical relevance in cardiovascular disease.
Does dexamethasone pretreatment abolish the insulin-induced increment of coronary flow reserve in healthy young men?
Insulin acts as a vasodilator in the coronary vasculature, and this effect is not centrally mediated by sympathetic activation as it remains unchanged by dexamethasone.
Laine et al. (2000) studied this question.
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