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PP associated with CAD severity and stroke risk; leaves open whether targeting PP improves outcomes in stable CAD.
Pulse pressure (PP), defined as the difference between systolic blood pressure (SBP) and diastolic blood pressure (DBP), is a marker for increased large arterial stiffness [1], and is a major independent predictor of cardiovascular mortality in both general and hypertensive populations [2]. Recent cohort studies have shown that elevated SBP is associated with increased risk of cardiovascular disease and predicts future cardiovascular events in patients with coronary artery disease (CAD) [3]. Furthermore, a “J-curve” was reported to exist for DBP for patients with CAD but not for those with renal disease or stroke prevention [4].
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Tokitsu et al. (2015) studied this question.
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