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April 29, 2019PLoS ONEOpen Access

Cost-effectiveness of increased influenza vaccination uptake against readmissions of major adverse cardiac events in the US

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Why the study?

Although influenza vaccination reduces MACE in cardiovascular disease, vaccination coverage for US individuals with heart disease was only 48% in the 2015-16 season.

Does increasing influenza vaccination coverage to 75% improve cost-effectiveness and prevent MACE readmissions in US ACS patients?

Population

Estimated 493,750 US ACS patients

Comparison

Increased influenza vaccination coverage (75% to 95%) vs current US coverage

Design

Monte Carlo decision-tree cost-effectiveness model

Authors

SPSamuel K. PeasahMMMartin I. MeltzerMVMichelle Vu

Discussion

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Overview

Modeling suggests higher influenza vaccination may be cost-effective for MACE prevention in CVD; leaves open real-world uptake and savings.

Structured PICO

Does increasing influenza vaccination coverage to 75% improve cost-effectiveness and prevent MACE readmissions in US ACS patients?

P
Population
Estimated 493,750 US acute coronary syndrome (ACS) patients, adults aged ≥ 18 years
I
Intervention
Increasing influenza vaccination coverage to 75% (and up to 95% incrementally) by discharge
C
Comparator
Current US influenza vaccination coverage (48%)
O
Outcome
Incremental cost/QALY gained (ICER) and incremental cost/MACE case averted

Increasing influenza vaccination rates to at least 80% among hospitalized ACS patients is cost-saving and averts additional MACE readmissions.

Cite This Study

Peasah et al. (2019) studied this question.

synapsesocial.com/papers/6a70b9df8031ec7bb1dc887fhttps://doi.org/10.1371/journal.pone.0213499
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Association Between Influenza Vaccination and Cardiovascular Outcomes in High-Risk Patients2013 · 519 citations
  2. 2Flu vaccination in acute coronary syndromes and planned percutaneous coronary interventions (FLUVACS) Study One-year follow-up2003 · 270 citations
  3. 3Health Care Resource Utilization and Costs Associated with Nonfatal Major Adverse Cardiovascular Events2015 · 29 citations
  4. 4Risk Factors for Rehospitalization for Acute Coronary Syndromes and Unplanned Revascularization Following Acute Myocardial Infarction2015 · 68 citations
  5. 5Acute Myocardial Infarction after Laboratory-Confirmed Influenza Infection2018 · 1,213 citations