July 30, 2009PLoS ONEOpen Access

Gene Remodeling in Type 2 Diabetic Cardiomyopathy and Its Phenotypic Rescue with SERCA2a

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Why the study?

Does SERCA2a gene transfer reverse transcriptional changes and hypertrophy in a rat model of type 2 diabetic cardiomyopathy?

Population

Otsuka Long-Evans Tokushima Fatty rat model of type 2 diabetes and isolated cardiomyocytes in vitro

Comparison

Gene transfer of SERCA2a vs Age-matched control hearts and diabetic hearts…

Design

Preclinical

Authors

IKIoannis KarakikesHeart Failure / Cardiomyopathy MKMaengjo KimRutgers, The State University of New Jersey LHLahouaria HadriMount Sinai Hospital

Discussion

Member takes

Implication

Hypothesis-generating for SERCA2a gene therapy in diabetic cardiomyopathy; human translation requires prospective trials.

Structured PICO

Does SERCA2a gene transfer reverse transcriptional changes and hypertrophy in a rat model of type 2 diabetic cardiomyopathy?

Population

Otsuka Long-Evans Tokushima Fatty rat model of type 2 diabetes and isolated cardiomyocytes in vitro

Intervention

Gene transfer of SERCA2a

Comparator

Age-matched control hearts and diabetic hearts without gene transfer

Outcome

Changes in gene expression profiles and diabetes-associated hypertrophysurrogate

SERCA2a gene transfer reverses pathological transcriptional profiles and reduces hypertrophy in a rat model of type 2 diabetic cardiomyopathy.

Cite This Study

Karakikes et al. (2009) studied this question.

synapsesocial.com/papers/6a70babc75498292b70a314e https://doi.org/10.1371/journal.pone.0006474

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Gene Remodeling in Type 2 Diabetic Cardiomyopathy and Its Phenotypic Rescue with SERCA2a

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Gene Remodeling in Type 2 Diabetic Cardiomyopathy and Its Phenotypic Rescue with SERCA2a

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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