What question did this study set out to answer?

To evaluate the comparability of sample-handling protocols in blood-based amyloid-β studies and address the methodological causes of inconsistent assay performance.

May 21, 2012Journal of Alzheimer s DiseaseOpen Access

Variability in Blood-Based Amyloid-β Assays: The Need for Consensus on Pre-Analytical Processing

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Authors

AWAndrew D. WattThe University of Melbourne KPKeyla PerezFlorey Institute of Neuroscience and Mental Health ARAlan RembachThe University of Melbourne

Discussion

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Implication

Systematic review reveals major sample-handling discrepancies across blood-based amyloid-β studies, highlighting the need for standardized pre-analytical protocols in Alzheimer disease screening.

Key Points

To evaluate the comparability of sample-handling protocols in blood-based amyloid-β studies and address the methodological causes of inconsistent assay performance.
Systematic review analyzing reported pre-analytical processing techniques across 87 published articles focused on blood amyloid-β quantification.
Evaluated consistency in sample collection, processing procedures, and quality of methodological reporting.
Substantial heterogeneity in basic pre-analytical sample-handling methodologies contributed directly to divergent amyloid-β assay findings across studies.
The majority of reviewed literature exhibited incomplete and deficient reporting of sample collection and processing protocols.

Cite This Study

Watt et al. (2012) studied this question.

synapsesocial.com/papers/6a70bb015d37378ac1dddf69 https://doi.org/10.3233/jad-2012-120058

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Implication

Systematic review reveals major sample-handling discrepancies across blood-based amyloid-β studies, highlighting the need for standardized pre-analytical protocols in Alzheimer disease screening.

Variability in Blood-Based Amyloid-β Assays: The Need for Consensus on Pre-Analytical Processing

Discussion

Member takes

Implication

Key Points

Cite This Study

Variability in Blood-Based Amyloid-β Assays: The Need for Consensus on Pre-Analytical Processing

Discussion

Member takes

Implication

Key Points

Cite This Study

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