Why the study?
Does continuous-flow LVAD implantation reduce circulating GDF-15 levels in patients with NYHA class IV non-ischaemic heart failure?
Does continuous-flow LVAD implantation reduce circulating GDF-15 levels in patients with NYHA class IV non-ischaemic heart failure?
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This editorial highlights that elevated GDF-15 in advanced heart failure is reversible with LVAD support and likely reflects peripheral end-organ dysfunction rather than direct myocardial production.
Wollert et al. (2012) studied this question.
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