What question did this study set out to answer?

This research aims to assess the frequency of structural valve deterioration (SVD) following transcatheter aortic valve implantation (TAVI).

July 6, 2017Heart

Structural valve deterioration after transcatheter aortic valve implantation

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Why the study?

What is the incidence of structural valve deterioration after TAVI in patients with severe symptomatic aortic stenosis?

Key Points

This research aims to assess the frequency of structural valve deterioration (SVD) following transcatheter aortic valve implantation (TAVI).
Conducted a systematic review and meta-analysis of observational studies from 2002 to September 2016.
Included studies with a minimum follow-up of 2 years post-TAVI.
Utilized the GRADE system to assess evidence quality and pooled incidence rates using a random effects model.
Thirteen studies involving 8914 patients reported an SVD incidence between 0 to 1.34 per 100 patient years.
The pooled SVD incidence was 28.08 per 10,000 patients/year (95% CI 2.46 to 73.44 per 100 patient years).
12% of patients with SVD underwent valve re-intervention, with moderate confidence in the evidence due to study inconsistency.

Structured PICO

What is the incidence of structural valve deterioration after TAVI in patients with severe symptomatic aortic stenosis?

Population

13 observational studies including 8,914 patients with severe symptomatic aortic stenosis who underwent TAVI and were followed for at least 2 years.

Intervention

Transcatheter aortic valve implantation (TAVI)

Outcome

Frequency of structural valve deterioration (SVD) post-TAVIsafety

Structural valve deterioration is an infrequent event within the first 5 years after TAVI, supporting its durability in the medium term.

Limitations

Inconsistency among studies
Lack of long-term follow-up (>10 years)

Discussion

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Implication

Reassures on intermediate-term SVD risk after TAVI in selected patients; leaves open longer-term durability in broader populations.

Cite This Study

Foroutan et al. (2017) studied this question.

synapsesocial.com/papers/6a70bb5931a3df824328fbe3 https://doi.org/10.1136/heartjnl-2017-311329

Topics

TAVR in low-risk patients Transcatheter aortic valve replacement

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Structural valve deterioration after transcatheter aortic valve implantation

Key Points

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Topics

Structural valve deterioration after transcatheter aortic valve implantation

Key Points

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Also Consider

Topics

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