Why the study?
Does alpha-blocker use increase the risk of hip fracture in men 65 years of age or older?
Does alpha-blocker use increase the risk of hip fracture in men 65 years of age or older?
Alpha-blocker use in older men is associated with an increased risk of hip fracture, particularly during the early period of treatment, highlighting the need for caution regarding orthostatic hypotension.
Supports early fall-prevention assessment with alpha-blockers in older men; leaves open causality and generalizability pending RCTs.
BACKGROUND: Alpha-blocker can result in falling and fractures because of adverse effect such as orthostatic hypotension due to vasodilatory effect. We investigated the association between the alpha-blocker and the risk of osteoporotic hip fractures using a nationwide claim database. METHODS: We identified 1,051,651 men 65 years of age or older who had prescription records of alpha-blocker from nationwide medical claim database, from 2007 to 2012. Alpha-blockers were classified as non-specific general (NSG), non-specific slow-release (NSSR), uro-specific general (USG), and uro-specific slow release (USSR). RESULTS: Total of 6,553 hip fractures were observed. The incidences of hip fracture within 1 year were higher than those of the reference periods in all type of alpha-blocker. Hazard ratio peaked at early period of alpha-blocker, and decreased with time, regardless of type of alpha-blocker. CONCLUSIONS: Use of alpha-blocker is associated with increased risk of hip fracture, especially in early use.
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Seo et al. (2015) studied this question.
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