Catalytic Asymmetric Bromoamination of Chalcones: Highly Efficient Synthesis of Chiral α‐Bromo‐β‐Amino Ketone Derivatives

Stand and deliver: The first highly regio- and enantioselective bromoamination of chalcones has been developed which proceeds via an unusual bromonium-based mechanism to deliver the title compounds. Excellent results were obtained using 0.05 mol % of the C2-symmetric N,N′-dioxide/scandium(III) complex under mild conditions (see scheme).