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Herein, we report an organocatalytic asymmetric Mannich addition/retro-Claisen cascade reaction between unsymmetrical 1,3-diones and in situ-generated N-Boc-protected alkynylimines, affording chiral β-aminoketone derivatives in good yields with high enantioselectivities. The obtained chiral β-aminoketone derivatives can be readily transformed into hydrogenated products and oxime derivatives, respectively.
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Zhang et al. (2026) studied this question.
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