Population
Erythrocyte Ca2+-transport ATPase and brain phosphodiesterase
Design
Preclinical
Authors
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May indicate direct ATPase interference beyond calmodulin; hypothesis-generating for antagonist mechanisms in cardiac Ca2+ regulation.
The investigated drugs may exert their inhibitory effect on calmodulin-regulated enzymes not solely via binding to calmodulin but also by interfering directly with the effector enzyme.
Gietzen et al. (1982) studied this question.
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