Key result
Compound 48/80 inhibits calmodulin-dependent enzymes more specifically than calmidazolium without suppressing independent activities.
Population
In vitro enzyme systems including brain phosphodiesterase, erythrocyte Ca2+-transporting ATPase…
Comparison
Compound 48/80 vs Calmidazolium
Design
Preclinical
Authors
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Provides a more specific research tool for calmodulin studies in vitro; leaves open translation to cardiovascular systems.
Compound 48/80 is a highly specific calmodulin antagonist that is superior to calmidazolium for studying the role of calmodulin in biological processes without inhibiting calmodulin-independent events.
K Gietzen (1983) studied this question. Compound 48/80 vs. Calmidazolium was evaluated on Effects on calmodulin-dependent and calmodulin-independent enzyme systems. Compound 48/80 was a more specific calmodulin antagonist than calmidazolium, inhibiting calmodulin-dependent enzymes without suppressing basal calmodulin-independent enzyme activities.
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