Why the study?
Preserved systolic function despite impaired energetics in obesity suggests resting ATP delivery is maintained, but this had never been explored in human obesity.
Does weight loss improve impaired myocardial energetics and ATP delivery during stress in obese individuals without cardiovascular disease?
Population
80 volunteers without coexisting cardiovascular disease (35 controls and 45 obese)
Comparison
Obese vs control volunteers, and obese before vs after dietary weight loss
Design
Physiological study with an interventional dietary weight loss component
Authors
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Hypothesis-generating for CK compensation in obese hearts; leaves open whether energetics drive HF progression.
Does weight loss improve impaired myocardial energetics and ATP delivery during stress in obese individuals without cardiovascular disease?
Obesity impairs the heart's ability to increase ATP delivery during stress, contributing to reduced systolic augmentation, but this energetic deficit is reversible with weight loss.
Rayner et al. (2020) studied this question.
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