Effect of insulin on glucose metabolism in the dog after portacaval transposition
Population
Unanesthetized dogs with Eck fistula and with portacaval transposition
Comparison
Insulin infusion vs Alternate route of administration and…
Design
Preclinical
Authors
Discussion
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Overview
Insulin suppresses hepatic glucose output independently of route in dogs; leaves open translation to human physiology and diabetes management.
Structured PICO
P
Population
Unanesthetized dogs with Eck fistula and with portacaval transposition
I
Intervention
Insulin infusion (administered alternately by systemic and intraportal routes)
C
Comparator
Alternate route of administration (systemic vs intraportal) and baseline/control values
O
Outcome
Hepatic glucose outputsurrogate
Insulin decreases hepatic glucose output in dogs regardless of whether it is administered systemically or intraportally.
Cite This Study
Starzl et al. (1965) studied this question.