Gatifloxacin-Induced Hyperglycemia

Letters21 December 2004Gatifloxacin-Induced HyperglycemiaMarc R. Happe, DO, Brian P. Mulhall, MD, Corinne L. Maydonovitch, BS, and Kent C. Holtzmuller, MDMarc R. Happe, DOFrom Walter Reed Army Medical Center, Washington, DC 20307.Search for more papers by this author, Brian P. Mulhall, MDFrom Walter Reed Army Medical Center, Washington, DC 20307.Search for more papers by this author, Corinne L. Maydonovitch, BSFrom Walter Reed Army Medical Center, Washington, DC 20307.Search for more papers by this author, and Kent C. Holtzmuller, MDFrom Walter Reed Army Medical Center, Washington, DC 20307.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-141-12-200412210-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Background: Fourth-generation fluoroquinolones are broad-spectrum antibiotics frequently used to treat a wide variety of infections. Gatifloxacin (Tequin, Bristol-Myers Squibb, Princeton, New Jersey) is one of the newest and most effective quinolones (1). A small number of cases in the literature have shown significant abnormalities in glucose homeostasis after the administration of gatifloxacin (1-3). To date, only 1 case of hyperosmolar nonketotic hyperglycemia associated with gatifloxacin use has been published (2).Objective: To describe 2 patients with liver disease who developed severe hyperosmolar nonketotic hyperglycemia temporally related to the administration of gatifloxacin.Case Reports: Patient 1, a 60-year-old ...References1. Ambrose PG, Bhavnani SM, Cirincione BB, Piedmonte M, Grasela TH. Gatifloxacin and the elderly: pharmacokinetic-pharmacodynamic rationale for a potential age-related dose reduction. J Antimicrob Chemother. 2003;52:435-40. [PMID: 12917247] CrossrefMedlineGoogle Scholar2. Biggs WS. Hypoglycemia and hyperglycemia associated with gatifloxacin use in elderly patients. J Am Board Fam Pract. 2003;16:455-7. [PMID: 14645336] CrossrefMedlineGoogle Scholar3. Donaldson AR, Vandiver JR, Finch CK. Possible gatifloxacin-induced hyperglycemia. Ann Pharmacother. 2004;38:602-5. [PMID: 14982977] CrossrefMedlineGoogle Scholar4. Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther. 1981;30:239-45. [PMID: 7249508] CrossrefMedlineGoogle Scholar5. Grasela DM, Christofalo B, Kollia GD, Duncan G, Noveck R, Manning JA, et al. Safety and pharmacokinetics of a single oral dose of gatifloxacin in patients with moderate to severe hepatic impairment. Pharmacotherapy. 2000;20:87S-94S. [PMID: 10850525] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Marc R. Happe, DO; Brian P. Mulhall, MD; Corinne L. Maydonovitch, BS; Kent C. Holtzmuller, MDAffiliations: From Walter Reed Army Medical Center, Washington, DC 20307.Disclaimer: The opinions or assertions contained herein are those of the authors and are not to be construed as official policy of the U.S. Department of the Army or the U.S. Department of Defense. 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