What question did this study set out to answer?

To identify preoperative and intraoperative risk factors influencing the incidence, onset time, and severity of breakthrough corneal haze following photorefractive keratectomy with mitomycin C.

May 23, 2017Cornea

Corneal Breakthrough Haze After Photorefractive Keratectomy With Mitomycin C: Incidence and Risk Factors

View Full Paper

Ask AI

Bookmark

Authors

IKIgor KaisermanBen-Gurion University of the Negev NSNa'ava SadiBarzilai Medical Center MMMichael MimouniTechnion – Israel Institute of Technology

Discussion

Member takes

Implication

Retrospective study reveals higher corneal haze risk in high refractive error corrections after PRK, suggesting longer mitomycin C exposure improves outcomes.

Key Points

To identify preoperative and intraoperative risk factors influencing the incidence, onset time, and severity of breakthrough corneal haze following photorefractive keratectomy with mitomycin C.
Retrospective analysis evaluated 7,535 eyes (N=3,854 patients; mean age 26 ± 6 years; 55% men) undergoing PRK with intraoperative mitomycin C (MMC) at a single center with 118 ± 110 days follow-up.
Eyes were stratified by baseline refraction categories (myopia, astigmatism, hyperopia), operative duration (<40 vs ≥40 seconds), and MMC exposure duration (<40 vs ≥40 seconds).
Breakthrough haze incidence was significantly elevated in high vs low-to-moderate myopia (2.1% vs 1.1%, P=0.002), high vs low astigmatism (3.5-fold higher, P<0.05), and hyperopia vs myopia (10.8% vs 1.3%, P=0.0001).
In moderate myopia, MMC application duration ≥40 seconds achieved a lower haze incidence than <40 seconds (0% vs 1.3%, P=0.03).
Mild early haze peaked at 68.8 ± 6 days postoperatively, whereas severe late haze peaked at 115 ± 17 days (P=0.02).

Cite This Study

Kaiserman et al. (2017) studied this question.

synapsesocial.com/papers/6a70c504e71d69abee08d4dc https://doi.org/10.1097/ico.0000000000001231

View Full Paper

Ask AI

Bookmark

May 23, 2017Cornea

Corneal Breakthrough Haze After Photorefractive Keratectomy With Mitomycin C: Incidence and Risk Factors

View Full Paper

Ask AI

Bookmark

Authors

IKIgor KaisermanBen-Gurion University of the Negev NSNa'ava SadiBarzilai Medical Center MMMichael MimouniTechnion – Israel Institute of Technology

Discussion

Member takes

Implication

Retrospective study reveals higher corneal haze risk in high refractive error corrections after PRK, suggesting longer mitomycin C exposure improves outcomes.

Key Points

To identify preoperative and intraoperative risk factors influencing the incidence, onset time, and severity of breakthrough corneal haze following photorefractive keratectomy with mitomycin C.
Retrospective analysis evaluated 7,535 eyes (N=3,854 patients; mean age 26 ± 6 years; 55% men) undergoing PRK with intraoperative mitomycin C (MMC) at a single center with 118 ± 110 days follow-up.
Eyes were stratified by baseline refraction categories (myopia, astigmatism, hyperopia), operative duration (<40 vs ≥40 seconds), and MMC exposure duration (<40 vs ≥40 seconds).
Breakthrough haze incidence was significantly elevated in high vs low-to-moderate myopia (2.1% vs 1.1%, P=0.002), high vs low astigmatism (3.5-fold higher, P<0.05), and hyperopia vs myopia (10.8% vs 1.3%, P=0.0001).
In moderate myopia, MMC application duration ≥40 seconds achieved a lower haze incidence than <40 seconds (0% vs 1.3%, P=0.03).
Mild early haze peaked at 68.8 ± 6 days postoperatively, whereas severe late haze peaked at 115 ± 17 days (P=0.02).

Cite This Study

Kaiserman et al. (2017) studied this question.

synapsesocial.com/papers/6a70c504e71d69abee08d4dc https://doi.org/10.1097/ico.0000000000001231

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark