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June 26, 2017European Journal of Preventive Cardiology

Epicardial, pericardial and total cardiac fat and cardiovascular disease in type 2 diabetic patients with elevated urinary albumin excretion rate

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Why the study?

Does high cardiac adipose tissue increase the risk of incident cardiovascular disease and mortality in patients with type 2 diabetes and elevated urinary albumin excretion rate?

Population

200 patients with type 2 diabetes and elevated urinary albumin excretion rate without coronary artery disease

Comparison

High cardiac adipose tissue measured by baseline… vs Low cardiac adipose tissue

Design

Cohort

Follow-up

6.1 years

Authors

RCRegitse Højgaard ChristensenBSBernt Johan von ScholtenCHChristian Stevns Hansen

Discussion

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Member takes

Overview

Cardiac adipose tissue may flag higher CVD risk in T2D; hypothesis-generating and requires validation before clinical use.

Structured PICO

Does high cardiac adipose tissue increase the risk of incident cardiovascular disease and mortality in patients with type 2 diabetes and elevated urinary albumin excretion rate?

P
Population
200 patients with type 2 diabetes and elevated urinary albumin excretion rate (UAER) without coronary artery disease
I
Intervention
High cardiac adipose tissue (epicardial and pericardial) measured by baseline echocardiography
C
Comparator
Low cardiac adipose tissue
O
Outcome
Composite endpoint of incident cardiovascular disease and all-cause mortalitycomposite

High cardiac adipose tissue is associated with an increased risk of incident cardiovascular disease and all-cause mortality in type 2 diabetes patients with elevated urinary albumin excretion rate, independent of traditional risk factors.

Cite This Study

Christensen et al. (2017) studied this question.

synapsesocial.com/papers/6a70c5815671bbf00bc2c484https://doi.org/10.1177/2047487317717820
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Also Consider

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  1. 1Elevated NT-proBNP and coronary calcium score in relation to coronary artery disease in asymptomatic type 2 diabetic patients with elevated urinary albumin excretion rate2011 · 27 citations
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  3. 3Threshold Values of High‐risk Echocardiographic Epicardial Fat Thickness2008 · 277 citations
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