Why the study?
Does rosiglitazone improve the metabolic profile and increase adiponectin levels in a fructose-fed rat model of metabolic syndrome?
Does rosiglitazone improve the metabolic profile and increase adiponectin levels in a fructose-fed rat model of metabolic syndrome?
In a rat model of metabolic syndrome, rosiglitazone improved the metabolic profile and increased plasma adiponectin levels, suggesting its beneficial effects may be mediated by adiponectin.
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Preclinical rat data should not change practice; hypothesis-generating for adiponectin mediation of rosiglitazone effects in metabolic syndrome.
Sharabi et al. (2007) studied this question.
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