Why the study?
Does a low-fat high-carbohydrate diet increase postprandial lipemia and other cardiovascular risk factors in patients with NIDDM compared to a higher-fat diet?
Population
Patients with non-insulin-dependent diabetes mellitus (NIDDM)
Comparison
Low-fat high-carbohydrate diet for 6 weeks vs Higher-fat lower-carbohydrate diet for 6 weeks…
Design
RCT, placed randomly
Follow-up
6 weeks per diet period
Authors
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High-carbohydrate diets worsen CV risk factor profiles in NIDDM; challenges historical low-fat diet recommendations.
Does a low-fat high-carbohydrate diet increase postprandial lipemia and other cardiovascular risk factors in patients with NIDDM compared to a higher-fat diet?
A low-fat high-carbohydrate diet in patients with NIDDM worsens glycemic and lipid profiles, demonstrating that diets historically recommended to reduce coronary heart disease risk may actually accentuate multiple risk factors.
Chen et al. (1995) studied this question.