September 1, 1991AJP Heart and Circulatory Physiology

Characterization of positive inotropic effect of endothelin on mammalian ventricular myocardium

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Population

Isolated ventricular myocardium from rabbit, guinea pig, rat, and dog

Design

Preclinical

Authors

MTMasahiro TakanashiYamagata University MEMakoto EndohYamagata Prefectural Central Hospital

Discussion

Member takes

Implication

Marked species differences in endothelin-1 inotropy caution against extrapolating animal data to patients; leaves open its role in human myocardial contractility.

Structured PICO

Population

Isolated ventricular myocardium from rabbit, guinea pig, rat, and dog

Intervention

Endothelin-1, -2, and -3

Outcome

Positive inotropic effect (PIE) and specific high-affinity binding of 125I-labeled endothelin-1surrogate

Endothelin induces a species-dependent positive inotropic effect in mammalian ventricular myocardium, likely involving phosphoinositide hydrolysis similar to alpha 1-adrenoceptor activation.

Cite This Study

Takanashi et al. (1991) studied this question.

synapsesocial.com/papers/6a70c7e4febe604dd7098c3a https://doi.org/10.1152/ajpheart.1991.261.3.h611

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Implication

Marked species differences in endothelin-1 inotropy caution against extrapolating animal data to patients; leaves open its role in human myocardial contractility.

Characterization of positive inotropic effect of endothelin on mammalian ventricular myocardium

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Characterization of positive inotropic effect of endothelin on mammalian ventricular myocardium

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider