Prolonged Antiplatelet Therapy to Prevent Late Thrombosis After Intracoronary γ-Radiation in Patients With In-Stent Restenosis
Why the study?
Does 6 months of clopidogrel and aspirin reduce late thrombosis in patients with in-stent restenosis treated with intracoronary gamma-radiation compared to 1 month of therapy?
Population
120 consecutive patients with diffuse in-stent restenosis in native coronary arteries and vein grafts with…
Comparison
Clopidogrel and aspirin for 6 months. vs Historical controls from the WRIST and LONG…
Design
Cohort
Follow-up
6 months
Authors
Discussion
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Member takes
Implication
Prolonged DAPT may lower late thrombosis after gamma-radiation for ISR; hypothesis-generating and requires randomized confirmation.
Structured PICO
Does 6 months of clopidogrel and aspirin reduce late thrombosis in patients with in-stent restenosis treated with intracoronary gamma-radiation compared to 1 month of therapy?
P
Population
120 consecutive patients with diffuse in-stent restenosis in native coronary arteries and vein grafts with lesions <80 mm who underwent percutaneous coronary transluminal angioplasty, laser ablation, and/or rotational atherectomy followed by intracoronary gamma-radiation.
I
Intervention
Clopidogrel and aspirin for 6 months.
C
Comparator
Historical controls from the WRIST and LONG WRIST studies (gamma-radiation-treated n=125, placebo n=126) who received only 1 month of antiplatelet therapy.
O
Outcome
Late thrombosis and total occlusion rates at 6 months.hard clinical
Prolonged dual antiplatelet therapy for 6 months is well tolerated and reduces late thrombosis after intracoronary gamma-radiation for in-stent restenosis compared to 1 month of therapy.
Cite This Study
Waksman et al. (2001) studied this question.