Why the study?
The study investigated relationships between perioperative blood transfusion, postoperative systemic inflammatory response, and outcomes following surgery for colorectal cancer.
Does perioperative blood transfusion increase postoperative systemic inflammatory response and worsen outcomes in patients undergoing surgery for colorectal cancer?
Population
544 patients undergoing potentially curative elective colorectal cancer surgery
Comparison
Perioperative blood transfusion vs no blood transfusion
Design
Single-center retrospective cohort study with propensity score matching
Authors
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May link transfusion to worse inflammation and outcomes after colorectal cancer surgery; hypothesis-generating, needs prospective trials before practice change.
Does perioperative blood transfusion increase postoperative systemic inflammatory response and worsen outcomes in patients undergoing surgery for colorectal cancer?
Perioperative blood transfusion during colorectal cancer surgery is associated with an exaggerated postoperative systemic inflammatory response, increased complications, and poorer overall survival.
McSorley et al. (2019) studied this question.
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