Key result
Perioperative transfusion of >2 blood units is linked to ~170% higher colorectal cancer mortality.
Why the study?
The association between perioperative blood transfusion and long-term outcome in colorectal cancer patients, including the effect of blood storage time, was unclear.
Does perioperative blood transfusion reduce long-term survival in patients undergoing curative resection for colorectal cancer?
Population
336 patients who survived resection with curative intent for colorectal cancer
Comparison
More than two units of blood transfused vs two or fewer units or no transfusion
Design
Cohort study with multivariate Cox proportional hazards regression analysis
Follow-up
Median 5.8 years (range 2-16.8 years)
Authors
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May support restrictive transfusion strategies in colorectal cancer surgery; hypothesis-generating and requires randomized confirmation.
Cohort (n=336)
Does perioperative blood transfusion reduce long-term survival in patients undergoing curative resection for colorectal cancer?
Hazard Ratio: 2.7 (95% CI 1.4–5.2)
Perioperative blood transfusion of more than two units is independently associated with poor prognosis and increased risk of death from colorectal cancer.
Edna et al. (1998) conducted a cohort in Colorectal cancer (n=336). Perioperative blood transfusion (>2 units) vs. No transfusion or ≤2 units of blood was evaluated on Death from colorectal cancer (HR 2.7, 95% CI 1.4-5.2). Perioperative transfusion of more than two units of blood was significantly associated with an increased risk of death from colorectal cancer (HR 2.7; 95% CI 1.4-5.2).
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