Population
Single voltage-clamped rat cardiac ventricular cells
Comparison
Depolarizing voltage-clamp pulses vs Different membrane potentials
Design
Preclinical
Authors
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Demonstrates variable gain in rat EC coupling; extends mechanistic insights but leaves open human relevance and therapeutic translation.
The study demonstrates 'variable gain' and 'interrupted SR Ca2+ release' in rat cardiac ventricular cells, providing insights into the local control of excitation-contraction coupling.
Wier et al. (1994) studied this question.
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