What does this research mean for the field?

The gain index of calcium release from the sarcoplasmic reticulum in cardiac cells is linearly correlated with the sarcoplasmic reticulum calcium load, such that reducing the load proportionally decreases the gain of calcium release triggered by calcium current. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

February 1, 1995AJP Heart and Circulatory Physiology

Effects of sarcoplasmic reticulum Ca2+ load on the gain function of Ca2+ release by Ca2+ current in cardiac cells

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Population

Whole cell voltage-clamped rat ventricular myocytes dialyzed with the Ca2+ indicator indo 1 salt at 23…

Comparison

Variable sarcoplasmic reticulum Ca2+ loading… vs Different levels of SR Ca2+ loading

Design

Preclinical

Authors

AJAndrzej M. JanczewskiUniversity of Warmia and Mazury in Olsztyn HSHarold A. SpurgeonElectrophysiology MSMichael D. SternElectrophysiology

Discussion

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Implication

Does not alter clinical Ca2+ handling management; leaves open translation of SR load-gain coupling beyond rodent myocytes.

Structured PICO

Population

Whole cell voltage-clamped rat ventricular myocytes dialyzed with the Ca2+ indicator indo 1 salt at 23 degrees C

Intervention

Variable sarcoplasmic reticulum (SR) Ca2+ loading graded by the duration of conditioning voltage-clamp steps

Comparator

Different levels of SR Ca2+ loading

Outcome

Changes in the gain index of Ca2+ release from the SR (ratio of the amount of Ca2+ released to the magnitude of the Ca2+ current integrated for the initial 20 ms of depolarization)surrogate

In rat ventricular myocytes, the gain index of Ca2+ release from the sarcoplasmic reticulum is linearly correlated with the SR Ca2+ load.

Cite This Study

Janczewski et al. (1995) studied this question.

synapsesocial.com/papers/6a1bccfc26cb5670aa9cea7f https://doi.org/10.1152/ajpheart.1995.268.2.h916

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Effects of sarcoplasmic reticulum Ca2+ load on the gain function of Ca2+ release by Ca2+ current in cardiac cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effects of sarcoplasmic reticulum Ca2+ load on the gain function of Ca2+ release by Ca2+ current in cardiac cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider