March 1, 1988Proceedings of the National Academy of SciencesOpen Access

Human apolipoprotein B (apoB) mRNA: identification of two distinct apoB mRNAs, an mRNA with the apoB-100 sequence and an apoB mRNA containing a premature in-frame translational stop codon, in both liver and intestine.

View Full Paper

Ask AI

Bookmark

Population

Human small intestinal and hepatic cDNA libraries and mRNA

Design

Preclinical

Authors

KHKeiichi HiguchiShinshu University AHAshok HospattankarHal Technology (United States)SLS W LawTufts University

Discussion

Member takes

Implication

Challenges tissue-specific apoB editing assumptions; leaves open mechanisms and relevance of hepatic apoB-48 production.

Structured PICO

Population

Human small intestinal and hepatic cDNA libraries and mRNA

Intervention

Hybridization with apoB-Stop and apoB-Gln synthetic probes and cDNA sequencing

Outcome

Presence of apoB-100 and apoB-48 mRNAs in liver and intestinesurrogate

This study demonstrates that the premature in-frame stop codon generating apoB-48 mRNA is not tissue-specific and is present in both human liver and intestine.

Cite This Study

Higuchi et al. (1988) studied this question.

synapsesocial.com/papers/6a70c898e5469ee92be177da https://doi.org/10.1073/pnas.85.6.1772

View Full Paper

Ask AI

Bookmark

Human apolipoprotein B (apoB) mRNA: identification of two distinct apoB mRNAs, an mRNA with the apoB-100 sequence and an apoB mRNA containing a premature in-frame translational stop codon, in both liver and intestine.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Human apolipoprotein B (apoB) mRNA: identification of two distinct apoB mRNAs, an mRNA with the apoB-100 sequence and an apoB mRNA containing a premature in-frame translational stop codon, in both liver and intestine.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider