Population
In vitro models studying the inositol 1,4,5-trisphosphate receptor 1 (IP3R1) macromolecular signaling complex
Design
Preclinical
Authors
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May refine IP3R1 calcium signaling models; leaves open in vivo cardiac effects and therapeutic relevance.
Demonstrates that regulation of IP3R1 function via PKA phosphorylation involves components of a macromolecular signaling complex including PP1 and PP2A.
deSouza et al. (2002) studied this question.
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