Key result
Calcium ion binding at concentrations <10(-7) M induces a conformational change in the type 1 IP3 receptor from a mushroom-like to a windmill-like structure, regulating channel opening.
This study provides structural evidence that Ca2+-specific conformational changes regulate IP3-triggered channel opening within the IP3R1 receptor.
No takes yet. Share an insight, caveat, or question.
No immediate clinical implications; extends structural understanding of IP3R1 but leaves open cardiac translation.
Hamada et al. (2003) studied this question. Calcium ion (Ca2+) vs. Without Ca2+ / Mg2+ was evaluated on Conformational changes in IP3R1. Calcium ion binding at concentrations <10(-7) M induces a conformational change in the type 1 IP3 receptor from a mushroom-like to a windmill-like structure, regulating channel opening.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: