Key result
Single-particle electron microscopy revealed the 3D structure of the type 1 inositol 1,4,5-trisphosphate receptor, showing a flower-like appearance with fourfold symmetry and three distinct domains.
Population
Type 1 inositol 1,4,5-trisphosphate receptor (IP3R)
Design
Preclinical
Authors
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Provides structural template for IP3R; extends Ca2+ channel research but leaves open therapeutic translation in cardiovascular disease.
This structural biology study reveals the 3D domain organization of the type 1 IP3R, providing a model for the location of its channel region and cytoplasmic binding subdomains.
Fonseca et al. (2003) studied this question. Single-particle electron microscopy revealed the 3D structure of the type 1 inositol 1,4,5-trisphosphate receptor, showing a flower-like appearance with fourfold symmetry and three distinct domains.
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