Why the study?
In vitro cell models do not entirely reflect in vivo lipid metabolism and accumulation, prompting investigation into whether conventional lipomas serve as a better model.
Superficial lipomas share a common lipid accumulation mechanism characterized by reduced lipolysis and decreased cAMP signaling, suggesting they could serve as a human tissue model for lipid accumulation in obesity.
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Lipomas may model reduced lipolysis-driven lipid accumulation in obesity; leaves open their utility as accessible human tissue for mechanistic studies.
Duc et al. (2020) studied this question.
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