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August 25, 2021International Journal of Molecular SciencesOpen Access

Effect of Angiotensin II on Chondrocyte Degeneration and Protection via Differential Usage of Angiotensin II Receptors

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Why the study?

The effects of angiotensin II exerted through AT1R and AT2R on chondrocyte metabolism are not fully understood.

Population

Rat chondrocytic RCS cells and 7-month-old mice

Comparison

ANG II and AT1R blockade vs control

Design

Preclinical laboratory study

Authors

TNTakashi NishidaSASho AkashiMTMasaharu Takigawa

Discussion

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Overview

May modulate chondrocyte proliferation via AT1R; leaves open clinical relevance in cartilage disease.

Structured PICO

P
Population
Rat chondrocytic RCS cells (wild-type and CRISPR-Cas9 generated Agtr1a-deficient) and articular cartilage of 7-month-old mice
I
Intervention
Angiotensin II (ANG II) and AT1R antagonist (losartan)
C
Comparator
Control/untreated cells
O
Outcome
Chondrocyte proliferation, glycosaminoglycan content, and expression of CCN2, MMP9, and Aggrecan (Acan)surrogate

AT1R blockade reduces Angiotensin II-induced chondrocyte degeneration in vitro, highlighting a potential mechanism for age-related cartilage degeneration.

Cite This Study

Nishida et al. (2021) studied this question.

synapsesocial.com/papers/6a70ca04a528af2d65c3bd7chttps://doi.org/10.3390/ijms22179204
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Activating types 1 and 2 angiotensin II receptors modulate the hypertrophic differentiation of chondrocytes2013 · 24 citations
  2. 2‘The road not taken’: role of angiotensin II type 2 receptor in pathophysiology2002 · 39 citations
  3. 3THE ROLE OF ANGIOTENSIN II TYPE 2 RECEPTORS (AT2RS) IN THE REGULATION OF CARDIO-RENAL AND NEUROPROTECTIVE ACTIVITIES: POTENTIAL THERAPEUTIC IMPLICATIONS2017 · 1 citations
  4. 4Blood pressure lowering and renin-angiotensin system blockade2003 · 43 citations
  5. 5Pathophysiological Role of Angiotensin II Type 2 Receptor in Cardiovascular and Renal Diseases1998 · 479 citations