What question did this study set out to answer?

To review evidence for the autonomous existence, physiological integration, and pharmacological modulation of the local tissue-resident renin-angiotensin system in the heart.

November 12, 2008Cardiology

Tissue Reuin-Angiotensin Systems and Their Modulation: The Heart as a Paradigm for New Aspects of Converting Enzyme Inhibition

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Design

Review

Authors

KLKlaus LindpaintnerBruker (United States)DGDetlev GantenGeneral / Preventive / Lipids

Discussion

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Implication

Supports tissue ACE inhibition in ischemia; leaves open clinical outcome benefits pending prospective trials.

Key Points

To review evidence for the autonomous existence, physiological integration, and pharmacological modulation of the local tissue-resident renin-angiotensin system in the heart.
Synthesized molecular and biochemical evidence on local cardiac expression and regulation of renin, angiotensinogen, and angiotensin-converting enzyme.
Assessed physiological data from isolated heart models evaluating the generation of angiotensins I and II and their response to enzyme inhibitors.
Cardiac tissue independently expresses renin and angiotensinogen genes and harbors angiotensin-converting enzyme to locally produce active angiotensins I and II.
Renin inhibitors and converting enzyme inhibitors dose-dependently block cardiac peptide activation cascades.
Tissue-level converting enzyme inhibition modulates angiotensin-mediated effects on cardiomyocyte structure, growth, and functional outcomes during myocardial ischemia.

Cite This Study

Lindpaintner et al. (2008) studied this question.

synapsesocial.com/papers/6a70ca06a528af2d65c3bd92 https://doi.org/10.1159/000174905

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Tissue Reuin-Angiotensin Systems and Their Modulation: The Heart as a Paradigm for New Aspects of Converting Enzyme Inhibition

Discussion

Member takes

Implication

Key Points

Cite This Study

Tissue Reuin-Angiotensin Systems and Their Modulation: The Heart as a Paradigm for New Aspects of Converting Enzyme Inhibition

Discussion

Member takes

Implication

Key Points

Cite This Study

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