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September 1, 1987Journal of Biological ChemistryOpen Access

Human renin is correctly processed and targeted to the regulated secretory pathway in mouse pituitary AtT-20 cells.

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Population

Mouse pituitary AtT-20 cells

Design

Preclinical

Authors

LFL C FritzGerman Cancer Research CenterMHM. HaidarAmerican University of Beirut Medical CenterAAAnn ArfstenScripps Research Institute

Discussion

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Implication

Does not support changes in clinical practice; leaves open whether nonrenal cells contribute to active renin in vivo.

Structured PICO

P
Population
Mouse pituitary AtT-20 cells
I
Intervention
Transfection with a gene that directs human prorenin synthesis
O
Outcome
Processing of prorenin to active renin and its regulated secretionsurrogate

Cellular elements capable of processing prorenin to active renin and directing its regulated release are present in nonrenal cell types.

Cite This Study

Fritz et al. (1987) studied this question.

synapsesocial.com/papers/6a70ca06a528af2d65c3bd9fhttps://doi.org/10.1016/s0021-9258(18)45217-9
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cloning and sequence analysis of cDNA for human renin precursor.1983 · 271 citations
  2. 2Human renal renin. Complete purification and characterization.1980 · 125 citations
  3. 3Characterization of inactive renin from human kidney and plasma. Evidence of a renal source of circulating inactive renin.1983 · 65 citations
  4. 4The Purification of a High-molecular-weight, Enzymatically Inactive Renin Precursor from Human Kidney1984 · 13 citations
  5. 5Interaction of Signals Influencing Renin Release1984 · 46 citations