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June 1, 1984Journal of Hypertension

The Purification of a High-molecular-weight, Enzymatically Inactive Renin Precursor from Human Kidney

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Population

Human kidney tissue

Design

Preclinical

Authors

GMGordon D. McIntyreResearch Triangle Park FoundationBPBernard PauCentre Occitanie-MontpellierAHAllan HallettNovartis (Switzerland)

Discussion

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Implication

No immediate clinical implications; extends foundational renin-angiotensin biology while leaving therapeutic relevance open.

Structured PICO

P
Population
Human kidney tissue
I
Intervention
Purification and activation (trypsin treatment, acid exposure)
O
Outcome
Identification and molecular weight characterization of human proreninsurrogate

This basic science study successfully purified and characterized human prorenin from kidney tissue, demonstrating its activation by trypsin and acid.

Cite This Study

McIntyre et al. (1984) studied this question.

synapsesocial.com/papers/6a70ca77ce524a4339c47bf1https://doi.org/10.1097/00004872-198406000-00014
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Human renal renin. Complete purification and characterization.1980 · 125 citations
  2. 2Pure human renin. Identification and characterization and of two major molecular weight forms.1981 · 92 citations
  3. 3Purification and characterization of human truncated prorenin1992 · 17 citations
  4. 4Characterization of pure human renal renin. Evidence for a subunit structure.1987 · 63 citations
  5. 5Pure Human Inactive Renin1989 · 33 citations