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January 1, 1987Journal of Biological ChemistryOpen Access

Characterization of pure human renal renin. Evidence for a subunit structure.

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Population

Human renal renin purified from 3 kg of human kidney cortex dissected from 10 kg of human cadaver kidney

Design

Preclinical

Authors

YSY SNizhny Novgorod Research Institute of Traumatology and OrthopedicsTSTatsuo ShinagawaHiroshima Red Cross Hospital & Atomic-bomb Survivors HospitalHTHelen TamOntario Universities’ Application Centre

Discussion

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Implication

Details human renin structure and activity; leaves open its regulatory role in plasma and tissues pending further study.

Structured PICO

P
Population
Human renal renin purified from 3 kg of human kidney cortex dissected from 10 kg of human cadaver kidney
I
Intervention
Purification using a three-step procedure including homogenization, ammonium sulfate precipitation, and affinity chromatography
O
Outcome
Biochemical characterization including molecular weight, pH optima, Km, and subunit structuresurrogate

The identification of subunit structures in pure human renal renin suggests a potential mechanism for the regulation of renin activity in plasma and tissues.

Cite This Study

S et al. (1987) studied this question.

synapsesocial.com/papers/6a70f23b8031ec7bb1dcaddahttps://doi.org/10.1016/s0021-9258(19)75746-9
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Pure human renin. Identification and characterization and of two major molecular weight forms.1981 · 92 citations
  2. 2Cloning and sequence analysis of cDNA for human renin precursor.1983 · 271 citations
  3. 3Molecular cloning and nucleotide sequence of a human renin cDNA fragment1983 · 82 citations
  4. 4Multiple Forms of Cathepsin D from Bovine Uterus1972 · 64 citations
  5. 5A human neutrophil-dependent pathway for generation of angiotensin II: purification and physicochemical characterization of the plasma protein substrate.1981 · 26 citations